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PhD Defense of Romain BANGE

Published on February 1, 2019
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PhD Defense February 18, 2019 | Access map
Defense of the doctoral thesis of BANGE Romain,  for the University Grenoble Alpes, speciality  " NANO ELECTRONICS & NANO TECHNOLOGIES ", entitled:
  Amphi M001 (RDC) - Phelma/Minatec
3 rue parvis Louis Néel
38016 Grenoble cedex1

Realization and optimization of biosensors based on SiC nanostructures for the electrical detection of DNA

Romain BANGE

Romain BANGE

Monday, February 18, 2019  at 10:30

biosensor, DNA, transistor, field effect, nanowire, silicon carbide

Sensing of low concentrations of nucleic acids is essential to a variety of applications such as bio-medical analysis, in which case it allows the diagnosis of pathologies by identifying specific biomarkers. Compared to traditional sensing techniques based on biochemistry, the advantage of electrical field-effect detection is that it relies on a direct, label-free, and fast-response measurement.  Transistors based on semiconducting nanowires are promising devices that theoretically enable very low detection limits and a high sensitivity, thanks to their high surface-to-volume ratio and unique electronic properties. Silicon carbide (SiC) is a semiconductor material with qualities such as very high physical and chemical stability and high biocompatibility, which make it particularly suited for aforementioned applications.
In this thesis, field-effect transistors based on Si and SiC nanowires were designed with a top-down approach to be fabricated using photolithography techniques. The Si-based process was developed and optimized in order to fabricate reproducible devices made of nanowires and nanoribbons. A detailed study was conducted to demonstrate the superior chemical stability of SiC nanowires over Si nanowires under physiological conditions. Based on these results, we investigated two ways of elaborating a thin SiC layer around these Si nanostructures to provide them with its chemical resistance in liquid medium. These reproducible core-shell Si/SiC devices were eventually functionalized and integrated into a microfluidic system in order to achieve novel measurements of DNA detection in real time and in liquid media.
Members of Jury :
  • Mrs Edwige BANO – IMEP-LAHC, Grenoble – Supervisor
  • Mrs Valérie STAMBOULI – LMGP, Grenoble – Co-supervisor
  • Mrs Anne-Marie HAGHIRI – C2N, Palaiseau – Reviewer
  • M. Konstantinos ZEKENTES – FORTH Institute, Héraklion (Grèce) – Reviewer
  • M. Arnaud MANTOUX – SIMAP, Grenoble – Examiner
  • M. Stephen SADDOW – University of South Florida, Tampa (États-Unis) – Examiner
  • M. Pascal MAILLEY – CEA Leti DTBS, Grenoble – Guest

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Thesis prepared in the  laboratory IMEP-LaHC , supervised by  BANO Edwige , supervisor and Valérie STAMBOULI , Co-supervisor .

Date of update August 22, 2019

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